Hi, I am new to this forum, don't really know why as I have a 13 year old daughter who has had JIA for 12 years. My daughter has been on methotrexate injections since Xmas last year, she went from a 15ml dose to 17.5ml, since increasing the dose she finds the injections very painful and is in tears every week. She says its not the needle going in but when the medicine goes in and after the needle is removed that really hurts. We have tried putting ice on the injection site and we apply the numbing cream for at least an hour beforehand but neither seem to really help. When the hospital showed us how to do the injections they used a freeze spray. Has anyone tried this at home. if so does it work, what's it called and where can I buy some? Any help or advice would be greatly appreciated to avoid the stress and pain caused every week.