I have been reading lots of your posts and have decided to join your mad house. I am a 37 yr old single mum and was diagnosed 2 1/2 yrs ago with sero-negative arthur. I suffer in my knees, wrists, thumbs, first finger knuckles, ankles and sacroiliac rh. I take 25mg of methotrexate by injection, celebrex, tramadol, leflunomide 10mg and venlafaxine for my obvious depression. I had a recent flare in my right knee and had to call the dr out for a big steriod injection to get me sorted, which helped after about a week, but since then the pain in my thumbs and across the backs of hands is ssoooo bad i can't do anything with them. Is there anything that helps regarding wrist/thumb braces that is worth buying? I am sure walking about with them stuck up my armpits is not a good look.