trials for new RA drug

salamander

Has anyone read the article in the Mail about this? Sound extremely interesting. Apparently, it is a protein that re-boots the immune system, if I understand it correctly. You have it by infusion. They are starting a trial now.

lizzieuk1

Just read it salamander sounds promising, in fact I was reading an article a few weeks ago about the lack of this protein in ra sufferers and wondering why they don't just top us up - spooky must have been my vibes working !!!

Let's hope it works I would guess there will be less nasty side effects but who knows!

Out of interest I also found out that the research which found the stop start part of the gene causing breast cancer will next be aimed at RA, then they just need to find out how to manipulate it and turn the damn thing off- I say just with a big emphasis!!

lizzieuk1

Also see that kings college have already done a 2 year trial with 34 people 2009-2011 so looks v promising from their initial data. Guess this is a follow up trial, larger sample group also over 2 years. Guess we can keep tabs via the kcl.ac.UK website.

salamander

Thanks for that info Lizzie. Couldn't find much more detail online, apart from studies in mice! Good news if it's already been trialled. I shall watch with interest.

p.s. can you post the link to the 2009-2011 trial, I can't find it on their website. thanks.

frogmorton

Wow!!

Great news very promising.

Thanks for the info both

Love

Toni xx

lizzieuk1

The page is http://WWW.controlled-trials.com/isrctn22288225 hope that works as my tablet doesn't copy and paste or rather I can't do that!!
It just details what the trial was etc but not the outcome I guess it must have been positive though for this new trial to take place. Another useful thing is to Google the bip(binding immunoglobulin protein) or they call it human stress hormone. If you look on wikipedia it has lots of interesting info on its properties many of which we can prob all identify with regards our systemic symptoms makes for interesting reading


Oh gosh realise I am a true science geek !

salamander

Thanks. I think BiP is a stress protein, from what I read, not a hormone. The major human stress hormone is cortisol. Nonetheless, interesting research and I look forward to hearing the results.

stickywicket

These days I'm comfortably settled on methotrexate but I do remember a time when I could only hope that, by the time my current stuff stopped working or did stuff it shouldn't, they'd have brought out something else. This looks promising. Thanks Salamander.

MumV

Hi all,

Thank you for all the things you share. I try and keep mindful of things in order to support my daughter, if needed. (Defeating aggressive JIA and 20).

I also spotted this article in the papers, Salamander, and this is the link on Arth Research if anyone is interested. Doesn't it sound interesting/hopefully promising, they say it is the result of 15 years research and could potentially help osteoporosis too. I don't get up false hopes but this is the first article that seems to just make practice sense.

But I am grateful for Methotrexate for my daughter.

http://www.arthritisresearchuk.org/news/press-releases/2013/february/first-in-human-trial-of-a-new-drug-for-rheumatoid-arthritis.aspx

Kind regards to all and thank you for allowing me to learn.

Mum V

lizzieuk1

salamander wrote:

Thanks. I think BiP is a stress protein, from what I read, not a hormone. The major human stress hormone is cortisol. Nonetheless, interesting research and I look forward to hearing the results.

quite right dont know why i wrote hormone (had explained that the abbreviation bip was for BI protein!!) think it was rather late and i was watching silent witness at same time as writing!! At least someone is on the ball!

salamander

lizzieuk1 wrote:

salamander wrote:

Thanks. I think BiP is a stress protein, from what I read, not a hormone. The major human stress hormone is cortisol. Nonetheless, interesting research and I look forward to hearing the results.

quite right dont know why i wrote hormone (had explained that the abbreviation bip was for BI protein!!) think it was rather late and i was watching silent witness at same time as writing!! At least someone is on the ball!

not always!

elnafinn

http://www.dailymail.co.uk/health/article-2275418/Natural-drug-offer-long-lasting-arthritis-relief-rebooting-immune-system.html?ito=feeds-newsxml#axzz2KRmRto4b

elnafinn

Thank you MumV for your posting. I too was especially interested to read that this could be a potential treatment for osteoporosis.

Elna x

MumV

Thanks Elnafinn.

Every hopeful