My wife has been on oral methotrexate (8 pills on Friday night) and Plaquenil for several years, and Leflunomide for a year. She has sero-negative RA, and the only blood indicators are sed rate and CRP. Those have been in the normal range for almost a year.
Due a problem with the rheumatologist (she dropped the ball on blood testing and had pushed her appointment back a month), the doctor wouldn't refill the methotrexate prescription until my wife had a blood test. As she'd already run out, she didn't take any for the second weekend in a row. She started having severe stomach cramps and diahrrea which Lomotil has not stopped.
Is this a side-effect of stopping Methotrexate cold-turkey, or something completely random that happened to coincide with stopping the methotrexate?