Advice on Biologic treatment

mouse2009
mouse2009 Member Posts: 19
edited 8. Aug 2017, 08:41 in Living with Arthritis archive
I am in the process of deciding which biologic treatment to go on due to my current treatment not working. I am on injectable Methotrexate once a week with various oral meds combined. My joint inflammation score four weeks ago was 6/10 now it's 10/10 and in a lot of pain. Been on same regime for a two years so this is a big change for me. Have been offered golimumab, etanercept or adalimumab and don't know which to choose - even after reading the literature and advice from Specialist Nurse [emoji85]. Has anyone had good results with any of the above? Also concerned about any weight gain as have put on weight with steroid injections. Sorry for long post... feeling lost.


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Comments

  • trepolpen
    trepolpen Member Posts: 504
    edited 30. Nov -1, 00:00
    You should talk to your consultant/nurse & take their advice , not been on adalimumab myself & hear good reports from it , only thing I would not go on golimumab , I had problems with it not working & then they doubled the dose & endded up in hospital with a bad infection

    as for etanercept , it did work but had a site reaction & had to stop it
  • dreamdaisy
    dreamdaisy Member Posts: 31,552
    edited 30. Nov -1, 00:00
    I know that all of these work well for some in that their symptoms are eased but others have little or no success. I am on my third anti-TNF and it has been my most successful in that my bloods are lovely which shows that my PsA is under control. I do not, however, feel any physical difference and my mobility has continued to decline; due to circumstances I began these far too late to make any noticeable and substantial difference. DD
  • mouse2009
    mouse2009 Member Posts: 19
    edited 30. Nov -1, 00:00
    Thanks for replying. Suppose end of the day its trial and error with these drugs!


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  • dreamdaisy
    dreamdaisy Member Posts: 31,552
    edited 30. Nov -1, 00:00
    It is and that is time-consuming and patience-testing in itself! Please let us know which you decide upon and how things progress (hopefully for the better, yes?) DD
  • Buka
    Buka Member Posts: 43
    edited 30. Nov -1, 00:00
    I have tried both Enbrel and Humira. Didn't have any success with Enbrel but the Humira was extremely effective for me. One interesting thing though - It wasn't effective straight away. I seem to remember it taking about 6 months before I really began to feel better. Then in 2011 I stopped taking it for a few weeks while undergoing surgery on my feet. When I resumed taking it, it was ineffective. I tried other things over the next 12 months with no success and eventually I asked to try the Humira one more time as we were running out of options and I remembered how well I felt in 2009 . Again it took a while and I had to persuade my rheumy though as he wanted to stop prescribing it. It took 8 months to kick in this time but five years later I am still taking it and my life is pretty good atm. Very few really painful days. It may or may not be the answer for you (we are all different) but to hear that these drugs can make a huge difference gives everyone a more positive outlook on this pretty horrible condition. I really hope whatever you choose works well for you. Good luck Mouse.

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