I have been looking for an avenue to report a major benefit I have received inadvertently which I believe deserves a wider audience but it is difficult to know how. Having suffered from gout for several years, I finally agreed to move to daily Allopurinol an established treatment that prevents gout by lowering uric acid levels. A very old (>300 years) drug for treating gout, Colchicine, is routinely prescribed when starting Allopurinol as the latter can cause a gout flare up in the beginning.
I am 80 years old and in addition to gout have suffered increasing arthritis of the joints in hands and knees for nearly a decade. At a recent review I reported to my GP that I had experienced a remarkable improvement in my arthritic condition, with greater flexibility and total absence of pain. I asked " Could it be due to the Colchicine?" My GP reckoned it was down to the Allopurinol but said "we'll see when you cease the Colchicine".
Within 8 days of stopping Colchicine, I had a very painful arthritic attack in my right knee which prevented me walking. I immediately treated it with two days of NSAID (Naproxen)and resumed the Colchicine (one 0.5mg tablet daily) and within days and now three weeks later I am totally pain free and flexible again.
If you google Colchicine or look in any reference book, you will only find references to its use in gout. I googled Colchicine and osteo-arthritis and found that there has been some research in recent years into its use in OA. Small studies, but all positive about its benefit and safety (see references below). Now no pharmaceutical company will be interested in trialing an old inexpensive drug and no salesman will be promoting it to GPs so how will the word spread? Perhaps Arthritis Research might finance a UK trial?