I'm currently on Sulph and Hydroxy, maximum dose. They're not working and been almost persistently in flare for months. Consultant will see me in 10 weeks. I'm worried because I was on Methotrexate and they stopped it because of LFT's. They gave me 4 weeks to clear it out my system, and let my liver rest, but just a couple of days before I started Sulph I had an EXTREME flare and ended up in hospital. As the Sulph takes around 3 months to start working properly, I had another extreme flare 4 weeks later. I'm terrified stopping current meds in case it happens again. Has anyone experience of coming off/changing DMARDs without being left covered? I'm wondering if it would be safer to reduce my dose slowly. I think biologics is the next step, but that won't happen before September. I'd appreciate your experience.