Methotrexate anxiety

In the 24 hours following my MTX dose I experience significant anxiety symptoms. Every month I’m surprised by this. My RA clinic nurse wasn’t aware of it- has anyone else experienced this?


  • Poppyjane
    Poppyjane Moderator Posts: 715

    Welcome @Libbylee to the online community,

    I understand that you experience significant anxiety symptoms in the 24 hours period after your dose of methotrexate. This too is not a side effect that I am aware of but I can ask our experienced health team if they have come across this symptom.

    Meanwhile I attach some links which you might find helpful

    How long have you been taking methotrexate ? Is it a new drug that your body is still adjusting to ? Do share with us more details of your journey with arthritis and the ways it affects your life.

    We have many members of the community who are willing to share their advice and support you, so do join in with the discussions and we look forward to hearing from you soon.

    Take Care

    Poppyjane ( Moderator)

    If it would be helpful to talk to someone ring the Helpline 0800 5200 520

    Monday - Friday 9.00a.m. - 6.00p.m.

  • Kitty
    Kitty Member Posts: 3,583

    I have experienced anxiety when taking MTX. But oddly this occurred aftr 3 years of taking it. I was on 25mg injections and using them successfully. But for some reason I became afraid of injecting myself. After treatment for cancer (during which time I was advised to stop taking MTX while having chemo). Afterwards U was diagnosed with Vasculitis and although I was still taking Leflunomide (and still am) My consultant suggested MTX for the Vasculitis. But I couldn't face injections. So I was started on 7.5 mg tablets along with Prednisolone. I still take this and have no worries about MTX at such a low dose. Pred was started at 40mg daily but has been reduced to 5mgdaily. I realize my circumstances were totally different to yours, but maybe hearing my story might help somehow. The only other suggestion I have, is to mention your anxiety to your consultant. She may decide to change your meds from MTX to Leflunomide, as it is at least as good as MTX. Maybe you could have a chat with the Helpline team.


    "Women and cats will do as they please, and men and dogs should relax and get used to the idea." Robert A Heinlein


    Hi Libbylee

    Thank you for posting on the forum. I’m sorry to hear that you are experiencing significant anxiety symptoms following your MTX dose.

    I have read Poppyjanes post to you which leaves me little to add, and I hope that you have found it helpful, I think the link which was given to mindfulness and mediation may be useful for you. For experiences of others, you might want to repost on the living with arthritis forum where I think you will have more responses.

    You are very welcome to call our freephone helpline: 0800 5200 520 (weekdays 9am-8pm) here we can take our time to talk through what’s going on for you and sometimes sharing that can be helpful.

    Best wishes


    Helpline advisor

  • bosh
    bosh Member Posts: 3,811

    It’s very interesting to read all this, I also take Methotrexate and experience anxiety, been taking it for about a year, my family members often seem to think it’s “all in my head”, I share your frustration.

  • Tom
    Tom Member Posts: 522

    I had a similar reaction to MTX injections. The consultant put me on Sulfasalazine, since when no problems.

  • Hi Libbylee

    I have noticed the same, though it starts a day or two before my injection is due. I've had anxiety for around 3 years, which is before I was diagnosed with arthritis. It was well under control until going on Methotrexate. I'm now experiencing issues similar to when the anxiety first started. I'm due to see a Rheumatology Nurse next week, so hopefully something can be done to address it.

    Has anyone else tried switching to a different DMARD to see if anything changes?

  • PeterJ
    PeterJ Administrator Posts: 872

    Hello @blancomiaow and welcome to the community. We are a friendly and supportive group and I hope that that will be your experience as well.

    I understand that you suffer from anxiety and that it was under control until you were on Methotrexate. It is good that you are seeing the Rh Nurse next week as maybe they will be able to make recommendations as to what medication is best. Anxiety is a horrible thing to suffer from (I know) in addition to arthritis so I hope they can sort it out, or see your GP.

    In the meantime our website has a lot of useful info and a good search function, some examples of which are below

    Please do keep posting and let us know how you get on and I do hope that your Rh Nurse can help you. I am sure others will connect as well and share their experiences.

    With very best wishes

    Peter (moderator)

    Need more help? - call our Helpline on 0800 5200 520 Monday to Friday 9am to 6pm