Methotrexate sickness- is this normal?

Lollipop51 Member Posts: 4

Hello everyone,

Our 15 year old son has JIA- he's been on Methotrexate injections since Jan 2020. It's helped a fair bit,but the sickness affects him badly,even with anti- emetics. He has the injection on a Sat eve and doesn't want to go out at all over the weekend and is off school every Monday due to the sickness. The team are aware+ he's now on Humira,with a view to reducing the Methotrexate to a tablet once a week when it's working.

Does anyone else have these issues with their child who is on Methotrexate? It is extremely tough for all the family.




  • Kazza52
    Kazza52 Member Posts: 74

    Hi Lorraine,

    So sorry to hear about your Son and it is sad when he is so young too.

    I have been taking Methotrexate tablets since 2016 (I am 53) and I can relate to your Son's side effects. I too have the feeling of nausea about an hour after taking my medication on a Friday evening and this lasts until Sunday evening. I find that having a glass of lemonade settles my stomach perhaps this might help settle his tummy.

  • Teemac34
    Teemac34 Member Posts: 2

    My daughter has the same issue and has been on MTX six years. We have to write off a day a week. Consultant recommended three lots of ondansetron- the evening of the injection and the next morning and evening. Can’t say we’ve seen a huge difference as yet.

    Sorry to not be more positive or helpful but I just wanted you to know it was pretty normal.