Coffee & MTX… what are your experiences?
It is thought that one of the mechanisms by which MTX works for RA at low dose, in addition to disrupting the fast multiplication of marauding T cells, is also by stimulating all cells to release adenosine. This is a powerful anti-inflammatory that blunts RA. Adenosine locks on to adenosine receptors and tones down the inflammation. But it also causes drowsiness.
Now… here’s an interesting article I read about caffeine and it’s impact on adenosine…
“Coffee doesn’t perk you up - it just staves off drowsy feelings
By Xantha Leatham, Deputy Science Editor
WHEN it comes to waking up in the morning, many of us rely on a cup of coffee to give us the kickstart we need.
But your flat white, americano or latte won’t actually give you extra energy - it borrows it, according to an expert.
Dr Emma Beckett, a molecular nutritionist from the University of Newcastle, said this ‘loan’ of feeling awake will eventually need to be repaid with sleep.
She explained that caffeine keeps away drowsiness by temporarily blocking a chemical called adenosine. This chemical helps regulate our sleep and wake cycle.
Eventually adenosine binds to its receptor - part of the cells that receive signals - which tells the cells to slow down, making us feel drowsy and sleepy. Caffeine can help us feel awake by binding to the adenosine receptor and preventing the chemical from triggering the sleepy feeling.
‘But there is a catch,’ Dr Beckett wrote on The Conversation website. ‘While it feels energising, this little caffeine intervention is more a loan of the awake feeling rather than a creation of any new energy.
‘This is because the caffeine won’t bind for ever and the adenosine that it blocks doesn’t go away. So eventually the caffeine breaks down, let’s go of the receptors and all that adenosine that has been waiting and building up latches on and the drowsy feeling comes back - sometimes all at once. So, the debt you owe the caffeine always eventually needs to be repaid, and the only real way to repay it is to sleep.’
-DailyMail Feb 2023
This makes sense to me and explains why when I have my regular cappuccino on my MTX day, the efficacy of MTX is much reduced, but I don’t get MTX nausea or drowsiness or brain fog. If I take MTX with no caffeine, empty stomach at night, I get nausea, drowsiness and brain fog until lunchtime the next day, but my joints are ever so happy that week!
Counter to that, the RA resumes if I have an excess of fruit, my guess is it’s the fructose, as ordinary sugar does not trigger my RA.
Any one else with interesting experiences with different food? Or notice different levels of RA attack?
BTW I am on 25mg MTX tabs.
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