I’m new to this site and joined after searching online for alternatives to Methotrexate.
I’m 43 and have had psoriasis for about 35 years. Painful joint symptoms developed over the last ten and I was diagnosed with psoriatic arthritis.
I’ve been taking methotrexate for over a year now and currently on a dose of 17.5mg with the standard 5mg folic acid 48hrs later.
The medicine is the only thing in all this time that has worked in terms of almost completely clearing my psoriasis, and the arthritis is much more manageable.
I do however really struggle with the side effects, and feel awful for a few days after administering. My mood is very low, I’m irritable, I feel anxious and forgetful and have reached a point where I feel I can no longer continue with the methotrexate.
I’ve tried taking this medication a number of ways - spitting the dose, increasing folic acid, lowering dose until it is still just about effective - but all have the same result.
I’ve raised this with my consultant and he suggested continuing but at my next meeting I would like to request an alternative.
My questions for the forum are; has anyone else had a similar experience with methotrexate and if so what alternative medications have you found to be the most effective?
ideally I’d like to find something that works just as well but without any mental side effects - I can cope with stomach ache, fatigue or skin irritation but not depression.
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