I've been to see my Rheumy today. I am currently on Enbrel (Etanercept) and have just chalked up 3 years on it, however this past year has been rough owing to one infection after another and the treatment being stop start. The Enbrel has been good for my RA but has caused havoc with my immune system. I am currently facing the prospect of life-time anti bios because of an going problem. My Rheumy is concerned that I am on the Enbrel as well as Anti-bios as they conflict one another but has said we'll leave it another 6 weeks to see how I go. The alternative, if I have to come off, is the above. Because I've had 2 back-fire on me over the years - MXT/Sulpha - And now I'm having problems with Enbrel he said I'd be ideal for a clinical trial (at Whipps Cross) but they won't take me because of the ongoing infections! I've had a look at the above on line and in comparison to other drugs it sounds like heavy artillery, it basically wipes out your B-Cells, you need to go to the hospital to get them to inject you, and then once a year for a top-up! Anyone else out there on this, or going on it soon?