I have just been prescribed methotrexate and took my first tablet yesterday but since taking it so many questions have come into my head!!!! Over the last year or so I have managed with anti-inflams and painkillers but over the last three months the pain and swelling has hit me like a sledge hammer and I can no longer cope with the pain. My consultant has changed my anti-inflam to celebrex to take along with the methotrexate. I am very worried about the side effects of both drugs, reading all the information makes it all look very scary. I went alone to see my consultant just this Thurs and came out a little upset and with so much to take in. I have been talking it over with my husband and I am now thinking whether I have jumped in too quickly and may be should just try the celebrex on its own to see if that works because if I am taking both together how do I know if the methotrexate is working or not, cos it may the new anti-inflam is doing the trick instead. Should I not take the methotrexate anymore?? After talking it over I now dont know what to do for the best and feel so anxious and keep getting very teary about it all!!! Sorry to waffle on but its my first time here and think this site will be a great help to me.