Hello anybody, I'm currently on 6 , 2.5 milligrams of methotrexate once a week, so far they are not working.

I've been on them 4 months , hands ,wrists knees shoulders and elbows still in pain . How many tablets does it take to work ?



  • Brynmor
    Brynmor Administrator Posts: 1,057

    Hi Brian and welcome to the Community.

    Methotrexate can take quite a while to start working, so it may be 3 to 12 weeks before you start to notice any difference. However, I would have thought that there would have been some change after 4 months. It may well be worth trying to get an appointment with your doctor to discuss your progress.

    We have a great page of information on methotrexate that you like to take a look at:

    Do join in across the Community, ask questions, call in for a chat and also to let us know how you are getting on.

    All best wishes


  • dreamdaisy
    dreamdaisy Member Posts: 31,558

    That is a very small dose so it may need to be increased. What are your bloods showng and what are you hoping it will do? I've taken meth for years, with other meds too; I currently inject 15ml per week and it is controlling disease activity. DD

    Have you got the despatches? No, I always walk like this. Eddie Braben
  • Brynmor
    Brynmor Administrator Posts: 1,057

    Hi @dreamdaisy When starting off on the course of medication, Methotrexate tablets come in two strengths: 2.5 mg and 10 mg. To avoid confusion, it’s recommended you only be given one strength, usually 2.5mg.

    Dosage is then reviewed after a period of time depending on the outcome until an optimal level of control is reached. 😃


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