MTX and weird dreams?

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ClaireT
ClaireT Member Posts: 4
edited 10. Jul 2025, 14:54 in Living with Arthritis archive

I started on a 15mg weekly injection of MTX for vasculitis in July which was increased to 20mg ten weeks ago. Simultaneously decreasing prednisolone by 1mg every fortnight, now down to 10mg. Luckily I find side effects of both manageable, but one new thing since the MTX is that I am getting the oddest and most vivid dreams. They’re not nightmares but my sleep is disrupted. Is this a known side effect of MTX? Has anyone else experienced this?

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  • Arthuritis
    Arthuritis Member Posts: 578

    @ClaireT Yes! I get those too, usually don’t recall most after. I think its the brain’s reaction to disruption as I also got those for weeks after catching covid pre RA. I’ve only just started oral mtx

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