MTX and weird dreams?


I started on a 15mg weekly injection of MTX for vasculitis in July which was increased to 20mg ten weeks ago. Simultaneously decreasing prednisolone by 1mg every fortnight, now down to 10mg. Luckily I find side effects of both manageable, but one new thing since the MTX is that I am getting the oddest and most vivid dreams. They’re not nightmares but my sleep is disrupted. Is this a known side effect of MTX? Has anyone else experienced this?



  • Arthuritis
    Arthuritis Member Posts: 445

    @ClaireT Yes! I get those too, usually don’t recall most after. I think its the brain’s reaction to disruption as I also got those for weeks after catching covid pre RA. I’ve only just started oral mtx