How soon did you give up on methotrexate?

Skap
Skap Member Posts: 8
edited 5. Aug 2025, 09:57 in Living with arthritis

I have a history of gastritis and started mtx last week on the lowest dose. Also 5mg daily folic acid for 6 days. I was already on hydroychloroquine and sulphasalazine.

I have constant nausea and my stomach is burning, also massive fatigue.

They are going to switch me to injections but I don't feel optimistic.

Has anyone seen fewer side effects with inject methotrexate?

My RA is very intermittant. I'm fine between flares but have been having extremely painfu; flares in different joints.

I'm thinking that without MTX at least I feel good some of the time.

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Comments

  • Naomi33
    Naomi33 Moderator Posts: 593

    Afternoon @Skap

    Regards to MTX I started like you on tablets then pen injections. Pain relief excellent but like you stomach not so good had blood test results and they showed problems with liver so I had to come off them.

    Have you spoken to your consultant or doctor ??

    I am now on Yuflyma new bio med so fingers crossed.

    Hope you get some answers soon.

    Best wishes @Naomi33

    Need more help? - call our Helpline on 0800 5200 520 Monday to Friday 9am to 6pm


  • Chip_peeps71
    Chip_peeps71 Member Posts: 18

    Hi, I was switched from 20mg oral methotrexate a week to the 20mg injections approx 2 months ago. I feel far less nauseous with the subcutaneous route, the fatigue I experience has become worse though.

  • frogmorton
    frogmorton Member Posts: 30,523

    Hi @Skap

    I put methotrexate, nausea and injections into the search engine and got the following threads:

    https://community.versusarthritis.org/search?domain=all_content&query=methotrexate%20nausea%20and%20injections&scope=site&source=community

    Worth a read?

    Good luck I really hope the injections help (())

    Toni x

  • janetv
    janetv Member Posts: 5

    I changed to injections due to nausea but unfortunately I still get horrible nausea for at least 36 hours after I take it, despite taking folic acid 6 days a week. I take it about 7pm so the nausea is at its worse at night. I get some relief from ginger -a biscuit or drink and find sweet foods make it worse. I know many find the injectios are better so hope it works for you.

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